Category Archives: Applications in medicine

Drug development and carbon-11

Summary of the properties of carbon-11 founding the unique role in drug development

 At the meeting of the German Society of Chemistry (Gesellschaft Deutscher Chemiker [GdCh]) in Berlin from 10 to 14 September 2017, Ehab Al-Momani and I will present a poster about the unique role of Carbon-11 in drug research, as it is practically completely neglected on the international level.

The poster will be introduced in a session by two slides emphasizing the properties of carbon-11 founding the unique features of this radionuclide in the field of drug development.

You can download the poster and the slides (PDF) from the link below or by clicking on the images to the left.
Poster Carbon 11 The unique yet neglected radionnuclide (Wissenschaftsforum Chemie 2017).

The unique role of carbon-11 in the field of pharmaceutical research and development of new drugs.


Preview of the poster, click to view PDF


 

Control of cancer therapy by PET

The image shows the strategy of applying PET in cancer therapy.

The PET method provides a stategy to a direct control of therapy on-going in the patients. After three weeks PET is repeated and may show success of therapy in case of a responder. If no effect is seen, therapy is stopped and strategy of treatment is changed.

Read more about this in the book (chapter 4.1).

Applications in medicine

The registration of biochemical processes directly within the organism makes the PET method a versatile tool for studying metabolic functions in both research and diagnostic examinations. Control of therapy is realized by directly analyzing corresponding metabolic alterations and, thus, in case of lacking response the reporting strategy can be changed immediately. That holds for oncological and neuropsychiatric diseases.

Moreover, the possibility of the direct transfer from the in-vitro to the in-vivo level allows the translation from the static to the dynamic biological system and exhibits a key feature in the PET method for drug development. Yet, the approach is rarely used during the past twenty years and the “tail” of extraordinarily high cost of a drug development keep to be spread around. With the PET method the promise of a new compound is seen in a study within a few mice modeling the particular disease. Even more, those data allow a direct translation to the clinical level with a few patients only.